MDMA Impairs Response to Water Intake in Healthy Volunteers
نویسندگان
چکیده
منابع مشابه
MDMA Impairs Response to Water Intake in Healthy Volunteers
Hyponatremia is a serious complication of 3,4-methylenedioxymethamphetamine (MDMA) use. We investigated potential mechanisms in two double-blind, placebo-controlled studies. In Study 1, healthy drug-experienced volunteers received MDMA or placebo alone and in combination with the alpha-1 adrenergic inverse agonist prazosin, used as a positive control to release antidiuretic hormone (ADH). In St...
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3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a psychostimulant drug producing heightened mood and facilitated social communication. In animal studies, MDMA effects are primarily mediated by serotonin (5-HT), but also by dopamine (DA) and possibly noradrenaline (NA). In humans, however, the neurochemical and neurophysiological basis of acute MDMA effects remains unknown. The distributi...
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ژورنال
عنوان ژورنال: Advances in Pharmacological Sciences
سال: 2016
ISSN: 1687-6334,1687-6342
DOI: 10.1155/2016/2175896